I would say safety is actually less of an issue here than it is in Graduate Hospital. Most of the area in Spruce Hill/Cedar Park neighborhoods is pretty safe overall for the city. If you're used to the levels of crime in GradHo, imo you would feel very comfortable in University City. Penn Alexander is great, although there is something of a line to get in now if I understand correctly. Neighboring districts aren't that bad and some are starting to consider them as viable choices. More than likely in the coming years that situation will improve as well.
"imagination and memory are but one thing, which for diverse considerations hath diverse names" - Thomas Hobbes